Methanol → 4-amino-1-[(2,2-dimethyl[1,3]dioxolan-4-yl)methyl]-2-ethoxymethyl-1H-imidazo[4,5-c]quinolin-7-ol

HRID 681066Notes

Reaction equation

HRID 681066 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][cH:11][c:12]2[c:13]3[c:14]([c:15]([NH2:19])[n:16][c:17]2[cH:18]1)[n:20][c:21]([CH2:31][O:32][CH2:33][CH3:34])[n:22]3[CH2:23][CH:24]1[O:25][C:26]([CH3:29])([CH3:30])[O:27][CH2:28]1.[CH3:35][OH:36].[CH3:37][C:38]#[N:39].[OH-:40].[OH-:42].[Pd+2:41]>>[OH:8][c:9]1[cH:10][cH:11][c:12]2[c:13]3[c:14]([c:15]([NH2:19])[n:16][c:17]2[cH:18]1)[n:20][c:21]([CH2:31][O:32][CH2:33][CH3:34])[n:22]3[CH2:23][CH:24]1[O:25][C:26]([CH3:29])([CH3:30])[O:27][CH2:28]1

Participants

6

Reactant 5

HCID 887MethanolHCID 961Hydroxide2×HCID 6342AcetonitrileHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 575453177-benzyloxy-1-[(2,2-dimethyl[1,3]dioxolan-4-yl)methyl]-2-ethoxymethyl-1H-imidazo[4,5-c]quinolin-4-ylamine

Product 1

HCID 1360751984-amino-1-[(2,2-dimethyl[1,3]dioxolan-4-yl)methyl]-2-ethoxymethyl-1H-imidazo[4,5-c]quinolin-7-ol

Sources & evidence

ORD record
ord-52fe8cbb73aa4e7aad4648f6c6a88842
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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