2,5-Difluorobenzenesulfonyl chloride → N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-2,5-difluorobenzenesulfonamide

HRID 681310Notes

Reaction equation

HRID 681310 reaction equation
[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:19]3[c:20]([F:27])[c:21]([NH2:22])[cH:23][cH:24][c:25]3[F:26])[n:10][c:11]([N:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1.[F:28][c:29]1[c:30]([S:36](=[O:37])(=[O:38])[Cl:39])[cH:31][c:32]([F:35])[cH:33][cH:34]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:19]3[c:20]([F:27])[c:21]([NH:22][S:36]([c:30]4[c:29]([F:28])[cH:34][cH:33][c:32]([F:35])[cH:31]4)(=[O:37])=[O:38])[cH:23][cH:24][c:25]3[F:26])[n:10][c:11]([N:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1

Participants

3

Reactant 2

HCID 27369112,5-Difluorobenzenesulfonyl chlorideHCID 57989700HCID 57989700, compound

Product 1

HCID 57989715N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-2,5-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-482fafaa79134790b0b0608a29b3048d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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