1,4-Dioxane → 2-methyl-2-(4-((2-(7-methyl-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)propanamide
Reaction equation
[Br:42][c:43]1[c:44]2[c:45]([c:46]([CH3:49])[n:47][cH:48]1)[nH:50][cH:51][cH:52]2.[Cu+:67].[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[c:8]3[c:9]([n:10][c:11]([Sn:13]([CH2:14][CH2:15][CH2:16][CH3:17])([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:22][CH2:23][CH2:24][CH3:25])[n:12]2)[cH:26][c:27]([CH2:29][N:30]2[CH2:31][CH2:32][N:33]([C:36]([C:37](=[O:38])[NH2:39])([CH3:40])[CH3:41])[CH2:34][CH2:35]2)[s:28]3)[CH2:5][CH2:6]1.[O:53]1[CH2:54][CH2:55][O:56][CH2:57][CH2:58]1.[cH:68]1[cH:69][cH:70][c:71]([P:72]([Pd:73]([P:74]([c:75]2[cH:76][cH:77][cH:78][cH:79][cH:80]2)([c:81]2[cH:82][cH:83][cH:84][cH:85][cH:86]2)[c:87]2[cH:88][cH:89][cH:90][cH:91][cH:92]2)([P:93]([c:94]2[cH:95][cH:96][cH:97][cH:98][cH:99]2)([c:100]2[cH:101][cH:102][cH:103][cH:104][cH:105]2)[c:106]2[cH:107][cH:108][cH:109][cH:110][cH:111]2)[P:112]([c:113]2[cH:114][cH:115][cH:116][cH:117][cH:118]2)([c:119]2[cH:120][cH:121][cH:122][cH:123][cH:124]2)[c:125]2[cH:126][cH:127][cH:128][cH:129][cH:130]2)([c:131]2[cH:132][cH:133][cH:134][cH:135][cH:136]2)[c:137]2[cH:138][cH:139][cH:140][cH:141][cH:142]2)[cH:143][cH:144]1.[s:59]1[cH:60][cH:61][cH:62][c:63]1[C:64]([O-:65])=[O:66]>>[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[c:8]3[c:9]([n:10][c:11](-[c:43]4[c:44]5[c:45]([c:46]([CH3:49])[n:47][cH:48]4)[nH:50][cH:51][cH:52]5)[n:12]2)[cH:26][c:27]([CH2:29][N:30]2[CH2:31][CH2:32][N:33]([C:36]([C:37](=[O:38])[NH2:39])([CH3:40])[CH3:41])[CH2:34][CH2:35]2)[s:28]3)[CH2:5][CH2:6]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-1cee2feec0f4476998219d9243227a96
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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