反应详情

5-Methylbenzofuran-7-ylamine (1.3 g, 8.8 mmol) and 10% palladium carbon (500 mg) were added to ethanol (50 ml), followed by conduction of catalytic reduction at room temperature under ordinary pressure. The catalyst was removed by celite filtration, and the obtained filtrate was condensed under reduced pressure. The residue was dissolved in dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure, giving a white powder of 5-methyl-2,3-dihydrobenzofuran-7-ylamine (1.15 g, yield: 87%).

1. customfollowed by conduction of catalytic reduction at room temperature under ordinary pressure
2. customThe catalyst was removed by celite filtration
3. customcondensed under reduced pressure
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated to dryness under reduced pressure