1,2-Dimethoxyethane → 7-(3-[1,4'-Bipiperidin]-1'-ylpropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile

HRID 681686Notes

Reaction equation

HRID 681686 reaction equation
[CH3:43][O:44][CH2:45][CH2:46][O:47][CH3:48].[Cl:1][CH2:2][CH2:3][CH2:4][O:5][c:6]1[c:7]([O:29][CH3:30])[cH:8][c:9]2[c:10]([NH:18][c:19]3[c:20]([Cl:28])[cH:21][c:22]([Cl:27])[c:23]([O:25][CH3:26])[cH:24]3)[c:11]([C:16]#[N:17])[cH:12][n:13][c:14]2[cH:15]1.[N:31]1([CH:37]2[CH2:38][CH2:39][NH:40][CH2:41][CH2:42]2)[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]1>>[CH2:2]([CH2:3][CH2:4][O:5][c:6]1[c:7]([O:29][CH3:30])[cH:8][c:9]2[c:10]([NH:18][c:19]3[c:20]([Cl:28])[cH:21][c:22]([Cl:27])[c:23]([O:25][CH3:26])[cH:24]3)[c:11]([C:16]#[N:17])[cH:12][n:13][c:14]2[cH:15]1)[N:40]1[CH2:39][CH2:38][CH:37]([N:31]2[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]2)[CH2:42][CH2:41]1

Participants

4

Reactant 3

HCID 80711,2-DimethoxyethaneHCID 786071,4'-BipiperidineHCID 110489207-(3-Chloropropoxy)-4-(2,4-dichloro-5-methoxyanilino)-6-methoxyquinoline-3-carbonitrile

Product 1

HCID 252528627-(3-[1,4'-Bipiperidin]-1'-ylpropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile

Sources & evidence

ORD record
ord-a7dc80a8c576475d9770ee058269ecfd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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