[3-(4-Oxo-piperidin-1-yl)-butyl]-carbamic acid tert-butyl ester → {3-[4-(2-Cyclohexylamino-1-{2,5-difluorophenyl}-ethylamino)-piperidin-1-yl]-butyl}-carbamic acid tert-butyl ester

HRID 682105Notes

Reaction equation

HRID 682105 reaction equation
[C:19]([CH3:20])([CH3:21])([CH3:22])[O:23][C:24]([NH:25][CH2:26][CH2:27][CH:28]([CH3:29])[N:30]1[CH2:31][CH2:32][C:33](=[O:36])[CH2:34][CH2:35]1)=[O:37].[CH:1]1([NH:7][CH2:8][CH:9]([NH2:10])[c:11]2[c:12]([F:18])[cH:13][cH:14][c:15]([F:17])[cH:16]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1>>[CH:1]1([NH:7][CH2:8][CH:9]([NH:10][CH:33]2[CH2:32][CH2:31][N:30]([CH:28]([CH2:27][CH2:26][NH:25][C:24]([O:23][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:37])[CH3:29])[CH2:35][CH2:34]2)[c:11]2[c:12]([F:18])[cH:13][cH:14][c:15]([F:17])[cH:16]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 68775260[3-(4-Oxo-piperidin-1-yl)-butyl]-carbamic acid tert-butyl esterHCID 86629532N2-cyclohexyl-1-(2,5-difluorophenyl)-ethane-1,2-diamine

Product 1

HCID 68776880{3-[4-(2-Cyclohexylamino-1-{2,5-difluorophenyl}-ethylamino)-piperidin-1-yl]-butyl}-carbamic acid tert-butyl ester

Sources & evidence

ORD record
ord-77aff563ba2942d7958b8721e2ce4d41
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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