Acetate → N-[6-(3-pyridyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-indazol-3-yl]butanamide

HRID 682189Notes

Reaction equation

HRID 682189 reaction equation
[C:44]([O-:45])(=[O:46])[CH3:47].[C:49]([O-:50])(=[O:51])[CH3:52].[CH2:1]([B:2]([CH2:3][CH3:10])[c:4]1[cH:5][n:6][cH:7][cH:8][cH:9]1)[CH3:11].[Cl:14][c:15]1[cH:16][cH:17][c:18]2[c:19]([NH:32][C:33]([CH2:34][CH2:35][CH3:36])=[O:37])[n:20][n:21]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:29])([CH3:30])[CH3:31])[c:22]2[cH:23]1.[Cs+:13].[F-:12].[O:38]1[CH2:39][CH2:40][O:41][CH2:42][CH2:43]1.[Pd+2:48]>>[c:4]1(-[c:15]2[cH:16][cH:17][c:18]3[c:19]([NH:32][C:33]([CH2:34][CH2:35][CH3:36])=[O:37])[n:20][n:21]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:29])([CH3:30])[CH3:31])[c:22]3[cH:23]2)[cH:5][n:6][cH:7][cH:8][cH:9]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 28179Fluoride IonHCID 312751,4-DioxaneHCID 104967Cesium cationHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 6428513-(Diethylboryl)pyridineHCID 10406687N-[6-chloro-1-[[2-(trimethylsilyl)ethoxy)methyl]-1H-indazol-3-yl)butanamide

Product 1

HCID 10386888N-[6-(3-pyridyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-indazol-3-yl]butanamide

Sources & evidence

ORD record
ord-63fbc7e9dd68408b8984a93d8873dde0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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