Benzyl 2-(3-hydroxyprop-1-en-1-yl)pyrrolidine-1-carboxylate → benzyl 2-[3-(2-bromo-4-cyano-N-(2,2,2-trifluoroacetyl)anilino)prop-1-enyl]pyrrolidine-1-carboxylate

HRID 682317Notes

Reaction equation

HRID 682317 reaction equation
[Br:20][c:21]1[c:22]([NH:23][C:24]([C:25]([F:26])([F:27])[F:28])=[O:29])[cH:30][cH:31][c:32]([C:34]#[N:35])[cH:33]1.[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH:12]([CH:16]=[CH:17][CH2:18][OH:19])[CH2:13][CH2:14][CH2:15]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH:12]([CH:16]=[CH:17][CH2:18][N:23]([c:22]2[c:21]([Br:20])[cH:33][c:32]([C:34]#[N:35])[cH:31][cH:30]2)[C:24]([C:25]([F:26])([F:27])[F:28])=[O:29])[CH2:13][CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 4266884Benzyl 2-(3-hydroxyprop-1-en-1-yl)pyrrolidine-1-carboxylateHCID 19970261N-(2-Bromo-4-cyanophenyl)-2,2,2-trifluoroacetamide

Product 1

HCID 53953431benzyl 2-[3-(2-bromo-4-cyano-N-(2,2,2-trifluoroacetyl)anilino)prop-1-enyl]pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-5744e82eb4c440b8af5845b782e03c34
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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