反应详情

Palladium on carbon (10%, 25 mg) was added to a solution of methyl 3-vinylpicolinate (120 mg, 0.74 mmol) in ethanol (10 mL). The suspension was stirred at room temperature under an atmosphere of hydrogen for 1 h before it was filtered through Celite and the pad of Celite was washed with methanol. The filtrate was concentrated down to dryness to yield methyl 3-ethylpicolinate (i.e. Cap-175, step b) which was taken directly into the next reaction. Rt=1.15 min (Cond.-MD1); LC/MS: Anal. Calcd. for [M+H]+ C9H12NO2: 166.09. found: 166.09.

1. filtrationwas filtered through Celite
2. washthe pad of Celite was washed with methanol
3. concentrationThe filtrate was concentrated down to dryness