反应详情

温度

85 °C

To a solution of the product of step 1 (10 g, 0.0275 moles) in ethanol (70 ml), a solution of potassium hydroxide (6.15 g, 0.1098 moles) in water (30 ml) was added and the reaction mixture was stirred at 80-90° C. for 36 hours. The reaction mixture was poured into ice cold water and extracted by dichloromethane. The combined dichloromethane extract was washed with water and brine, dried over sodium sulphate and evapourated under reduced pressure to yield 7.5 gm (84%) of product as liquid.

1. additionThe reaction mixture was poured into ice cold water
2. extractionextracted by dichloromethane
3. extractionThe combined dichloromethane extract
4. washwas washed with water and brine
5. dry with materialdried over sodium sulphate