HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 6833Generated: October 26, 2026
Diisopropylethylamine → (4-Benzyloxyphenyl)-(6-(5-(1,3-dioxolan-2-yl)-furan-2-yl)-7-fluoro-quinazolin-4-yl)-amine
https://huagongshe.com/reaction/6833
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Stannane, tributyl[5-(1,3-dioxolan-2-yl)-2-furanyl]- | HCID 10960952 | — |
| Reactant | (4-Benzyloxyphenyl)-(6-iodo-7-fluoroquinazolin-4-yl)-amine hydrochloride | HCID 21952109 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (4-Benzyloxyphenyl)-(6-(5-(1,3-dioxolan-2-yl)-furan-2-yl)-7-fluoro-quinazolin-4-yl)-amine | HCID 21951946 | — |
Reaction Steps
Prepared according to Procedure B from a solution of (4-benzyloxyphenyl)-(6-iodo-7-fluoro-quinazolin-4-yl)-amine hydrochloride (508 mg, 1 mmole), 5-(1,3-dioxolan-2-yl)-2-(tributylstannyl)furan (645 mg, 1.5 mmole), diisopropylethyl amine (650 mg, 5 mmole), and dichlorobis(triphenylphosphine) palladium (140 mg, 0.2 mmole) in 6 ml of DMF under nitrogen was stirred at 100° C. (oil bath temperature) for 4 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07084147B2 |
|---|
| Source dataset | uspto-grants-2006_08 |
|---|
| ORD ID | ord-e0606d7ad44d468bb930ce3610f78c51 |
|---|
| Source note | uspto-grants-2006_08 |
|---|
