1-[4-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazine → [5-Methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-{4-[4-(2,2,2-trifluoro-ethyl)-thiazol-2-yl]-piperazin-1-yl}-methanone

HRID 683363Notes

Reaction equation

HRID 683363 reaction equation
[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([O:14][CH:15]([C:16]([F:17])([F:18])[F:19])[CH3:20])[c:9]([C:10](=[O:11])[OH:12])[cH:13]1.[F:21][C:22]([CH2:23][c:24]1[n:25][c:26]([N:29]2[CH2:30][CH2:31][NH:32][CH2:33][CH2:34]2)[s:27][cH:28]1)([F:35])[F:36]>>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([O:14][CH:15]([C:16]([F:17])([F:18])[F:19])[CH3:20])[c:9]([C:10](=[O:12])[N:32]2[CH2:31][CH2:30][N:29]([c:26]3[n:25][c:24]([CH2:23][C:22]([F:21])([F:35])[F:36])[cH:28][s:27]3)[CH2:34][CH2:33]2)[cH:13]1

Participants

3

Reactant 2

HCID 211001721-[4-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazineHCID 211003065-Methylsulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid

Product 1

HCID 21100307[5-Methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-{4-[4-(2,2,2-trifluoro-ethyl)-thiazol-2-yl]-piperazin-1-yl}-methanone

Sources & evidence

ORD record
ord-27c45ff26e9a43138fb1df9b7646552d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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