1-[4-(Trifluoromethyl)-1,3-thiazol-2-yl]piperazine → [5-Methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-[4-(4-trifluoromethyl-thiazol-2-yl)-piperazin-1-yl]-methanone

HRID 683462Notes

Reaction equation

HRID 683462 reaction equation
[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([O:14][CH:15]([C:16]([F:17])([F:18])[F:19])[CH3:20])[c:9]([C:10](=[O:11])[OH:12])[cH:13]1.[F:21][C:22]([c:23]1[n:24][c:25]([N:28]2[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]2)[s:26][cH:27]1)([F:34])[F:35]>>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[cH:6][cH:7][c:8]([O:14][CH:15]([C:16]([F:17])([F:18])[F:19])[CH3:20])[c:9]([C:10](=[O:12])[N:31]2[CH2:30][CH2:29][N:28]([c:25]3[n:24][c:23]([C:22]([F:21])([F:34])[F:35])[cH:27][s:26]3)[CH2:33][CH2:32]2)[cH:13]1

Participants

3

Reactant 2

HCID 137478101-[4-(Trifluoromethyl)-1,3-thiazol-2-yl]piperazineHCID 211003065-Methylsulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid

Product 1

HCID 21100308[5-Methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-[4-(4-trifluoromethyl-thiazol-2-yl)-piperazin-1-yl]-methanone

Sources & evidence

ORD record
ord-b8cd1caa6f6c4f5d8b333e238f7bcd05
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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