4-(Pyrrolidin-1-yl)aniline → 4-[[2-(2-cyano-4-fluoropyrrolidin-1-yl)-2-oxoethyl]amino]-N-(4-pyrrolidin-1-ylphenyl)bicyclo[2.2.2]octane-1-carboxamide

HRID 683565Notes

Reaction equation

HRID 683565 reaction equation
[C:1](=[O:2])([OH:3])[C:4]12[CH2:5][CH2:6][C:7]([NH:12][CH2:13][C:14](=[O:15])[N:16]3[CH:17]([C:22]#[N:23])[CH2:18][CH:19]([F:21])[CH2:20]3)([CH2:8][CH2:9]1)[CH2:10][CH2:11]2.[N:24]1([c:29]2[cH:30][cH:31][c:32]([NH2:33])[cH:34][cH:35]2)[CH2:25][CH2:26][CH2:27][CH2:28]1>>[C:1](=[O:2])([C:4]12[CH2:5][CH2:6][C:7]([NH:12][CH2:13][C:14](=[O:15])[N:16]3[CH:17]([C:22]#[N:23])[CH2:18][CH:19]([F:21])[CH2:20]3)([CH2:8][CH2:9]1)[CH2:10][CH2:11]2)[NH:33][c:32]1[cH:31][cH:30][c:29]([N:24]2[CH2:25][CH2:26][CH2:27][CH2:28]2)[cH:35][cH:34]1

Participants

3

Reactant 2

HCID 8088414-(Pyrrolidin-1-yl)anilineHCID 231496734-[[2-(2-Cyano-4-fluoropyrrolidin-1-yl)-2-oxoethyl]amino]bicyclo[2.2.2]octane-1-carboxylic acid

Product 1

HCID 231505214-[[2-(2-cyano-4-fluoropyrrolidin-1-yl)-2-oxoethyl]amino]-N-(4-pyrrolidin-1-ylphenyl)bicyclo[2.2.2]octane-1-carboxamide

Sources & evidence

ORD record
ord-dc448301587b4f9fbf4572c31fbc330b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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