Sodium hydride → 2-(1-{[2-(Trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrazine

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(4H-imidazol-2-yl)pyrazine (0.75 g, 5.1 mmol) in DMF (7 mL) was added sodium hydride (60% dispersion in oil, 0.42 g, 10.3 mmol) and the reaction stirred at 40° C. for 2 hours. [2-(chloromethoxy)ethyl](trimethyl)silane (1.71 g, 10.3 mmol) was added and the reaction was stirred at 40° C. for a further 3 hours The reaction mixture was partitioned between EtOAc and water and the layers separated. The aqueous layers was extracted with EtOAc (×2) and the combined organic layers were dried (MgSO4), filtered and concentrated in vacuo. The residue was purified using column chromatography (gradient 20-60% EtOAc in hexane) to give the title compound (0.88 g, yellow oil). 1H NMR (400 MHz, CDCl3) δ ppm: 9.47 (d, J=1.0 Hz, 1 H), 8.36-8.59 (m, 2 H), 7.26-7.28 (m, 1 H), 7.24 (d, J=1.3 Hz, 1 H), 5.96-6.00 (m, 2 H), 3.53-3.61 (m, 2 H), 0.86-0.94 (m, 2 H), −0.10-−0.05 (m, 9 H).

Provenance & Evidence