1-[(5-Bromo-2-thienyl)sulfonyl]-4-methylpiperazine → 7-Difluoromethyl-3-[5-(4-methyl-piperazine-1-sulfonyl)-thiophen-2-ylethynyl]-5-(3-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

HRID 683825Notes

Reaction equation

HRID 683825 reaction equation
[Br:25][c:26]1[cH:27][cH:28][c:29]([S:31](=[O:32])(=[O:33])[N:34]2[CH2:35][CH2:36][N:37]([CH3:40])[CH2:38][CH2:39]2)[s:30]1.[C:1](#[CH:2])[c:3]1[cH:4][n:5][n:6]2[c:7]1[n:8][c:9](-[c:15]1[cH:16][c:17]([C:21]([F:22])([F:23])[F:24])[cH:18][cH:19][cH:20]1)[cH:10][c:11]2[CH:12]([F:13])[F:14]>>[C:1](#[C:2][c:26]1[cH:27][cH:28][c:29]([S:31](=[O:32])(=[O:33])[N:34]2[CH2:35][CH2:36][N:37]([CH3:40])[CH2:38][CH2:39]2)[s:30]1)[c:3]1[cH:4][n:5][n:6]2[c:7]1[n:8][c:9](-[c:15]1[cH:16][c:17]([C:21]([F:22])([F:23])[F:24])[cH:18][cH:19][cH:20]1)[cH:10][c:11]2[CH:12]([F:13])[F:14]

Participants

3

Reactant 2

HCID 6621571-[(5-Bromo-2-thienyl)sulfonyl]-4-methylpiperazineHCID 866080813-Ethynyl-7-difluoromethyl-5-(3-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 670007977-Difluoromethyl-3-[5-(4-methyl-piperazine-1-sulfonyl)-thiophen-2-ylethynyl]-5-(3-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Sources & evidence

ORD record
ord-892681c2bcfc4dc38d17bbd65eaf9816
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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