HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 6-(tert-butyl)phthalazin-1(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 5-tert-Butyl-3-ethoxy-3H-isobenzofuran-1-one | HCID 58016209 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-(tert-butyl)phthalazin-1(2H)-one | HCID 57633933 | 92.3% |
Reaction Steps
2.9 g (12 mmol) of 5-tert-butyl-3-ethoxy-3H-isobenzofuran-1-one was weighed into a 50 mL round bottom flask fitted with a stir bar and cap. Added 10 mL (130 mmol) of hydrazine monohydrate. Added 15 mL of glacial acetic acid. Stirred at 100° overnight. Poured the reaction mixture into 200 mL of stirred water. Collected the solids by filtration and washed with water. Dried under high vacuum to obtain 2.24 g of the title compound as an off-white solid. MS (ESI) 203 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822457B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-d34e3477313b4297b02b331df6282e73 |
| Source note | uspto-grants-2014_09 |