5-Chloro-N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide → 5-Chloro-n-{[(5s)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}-2-thiophenecarboxamide n-oxide

HRID 68473Notes

Reaction equation

HRID 68473 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH2:10][C@@H:11]2[O:15][C:14](=[O:16])[N:13]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[C:19]([F:29])[CH:18]=3)[CH2:12]2)=[O:8])=[CH:4][CH:3]=1.C1C=C([O:36]O)C(C(O)=O)=C(C(O)=O)C=1>>[Cl:1][C:2]1[S:6][C:5]([C:7]([NH+:9]([O-:36])[CH2:10][C@H:11]2[O:15][C:14](=[O:16])[N:13]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:24][CH2:25][O:26][CH2:27][CH2:28]4)=[C:19]([F:29])[CH:18]=3)[CH2:12]2)=[O:8])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 101381145-Chloro-N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamideHCID 198097063-Hydroperoxyphthalic acid

Product 1

HCID 870643435-Chloro-n-{[(5s)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}-2-thiophenecarboxamide n-oxide

Procedure

is obtained by treating 5-chloro-N-{[(5S)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}-2-thiophenecarboxamide from Example 1 with the magnesium salt of monoperoxyphthalic acid.

Workup

  1. customis obtained

Sources & evidence

ORD record
ord-ca3a863c972e4ddba7febfd6ba6f603d
Source dataset
uspto-grants-2014_09
Patent number
US08822458B2

Reaction notes

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