Ethanol → (3aRS,4RS,7SR,7aRS)-7-(hydroxymethyl)-4-(2-methoxyphenyl)-7-methyl-4-perhydroisoindolol

HRID 684968Notes

Reaction equation

HRID 684968 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]2[C:11]([CH3:26])([CH2:27][OH:28])[CH2:12][CH2:13][C:14]([OH:17])([c:18]3[c:19]([O:24][CH3:25])[cH:20][cH:21][cH:22][cH:23]3)[CH:15]2[CH2:16]1.[CH3:34][CH2:35][OH:36].[H:29][H:30].[OH-:31].[OH-:33].[Pd+2:32]>>[NH:8]1[CH2:9][CH:10]2[C:11]([CH3:26])([CH2:27][OH:28])[CH2:12][CH2:13][C:14]([OH:17])([c:18]3[c:19]([O:24][CH3:25])[cH:20][cH:21][cH:22][cH:23]3)[CH:15]2[CH2:16]1

Participants

6

Reactant 5

HCID 702EthanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 67714334(3aRS,4RS,7SR,7aRS)-2-benzyl-7-(hydroxymethyl)-4-(2-methoxyphenyl)-7-methyl-4-perhydroisoindololHCID 178418361HCID 178418361, compound

Product 1

HCID 67714238(3aRS,4RS,7SR,7aRS)-7-(hydroxymethyl)-4-(2-methoxyphenyl)-7-methyl-4-perhydroisoindolol

Sources & evidence

ORD record
ord-68f081b2adec44bbb1d1dd5f402b1829
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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