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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 685220Generated: October 30, 2026

Trifluoroacetic acid → rac-(2'S,3'R,4'R,5'R)-6-chloro-4'-(3-chloro-5-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-cyano-2-methoxy-phenyl)-amide

https://huagongshe.com/reaction/685220

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantDiphenylphosphinic chlorideHCID 73910—
ReactantDiisopropylethylamineHCID 81531—
Reactant4-Amino-3-methoxybenzonitrileHCID 11815931—
Reactant6-chloro-3'-(3-chloro-5-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxylic acidHCID 66633018—
Productrac-(2'S,3'R,4'R,5'R)-6-chloro-4'-(3-chloro-5-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-cyano-2-methoxy-phenyl)-amideHCID 75985333—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (3/10)
ORD IDord-1e731a13ccde458ca9ce7039391e395f
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (3/10)