反应详情

To a solution of N-(3-benzyloxy-phenyl)guanidine (5.0 g, 20.6 mmol) in EtOH (150 mL) was added palladium on carbon (10%, wet, 50% water, 0.5 g)). The mixture was stirred under hydrogen atmosphere overnight. The reaction was filtered through a plug of celite and the filtrate concentrated in vacuo with toluene azeotroping to affored the desired material (2.83 g, 91%). 1H-NMR (MeOH-d4) δ 6.4–7 (m, 4H)

1. filtrationThe reaction was filtered through a plug of celite
2. concentrationthe filtrate concentrated in vacuo with toluene azeotroping