HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetophenone → 1-(4-Fluoro-3-methyl-phenyl)-3-phenyl-1,3-propanedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetophenone | HCID 7410 | — |
| Reactant | Methyl 4-fluoro-3-methylbenzoate | HCID 18788764 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-Fluoro-3-methyl-phenyl)-3-phenyl-1,3-propanedione | HCID 82120449 | — |
Reaction Steps
17.3 g KOtBu was dissolved in 500 mL THF and 9 mL acetophenone was added. After 15 min at RT 25.9 g 4-fluoro-3-methyl-benzoic acid methyl ester was added and stirred for 3 h at RT. The solvent was removed and the residue was purified by chromatography on silica gel (cyclohexane/EE: 98:2) to yielded 19.3 g of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822464B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-1e25565a25144251bb4ccb2e655ee1af |
| Source note | uspto-grants-2014_09 |