2-(Trifluoromethoxy)benzene-1-sulfonyl chloride → (5RS,6RS)-6-Hydroxy-8-(2-trifluoromethoxy-benzenesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

HRID 685634Notes

Reaction equation

HRID 685634 reaction equation
[F:24][C:25]([O:26][c:27]1[c:28]([S:33](=[O:34])(=[O:35])[Cl:36])[cH:29][cH:30][cH:31][cH:32]1)([F:37])[F:38].[OH:1][CH:2]1[C:3]2([CH2:4][CH2:5][N:6]([c:9]3[cH:10][cH:11][c:12]([O:15][C:16]([F:17])([F:18])[F:19])[cH:13][cH:14]3)[C:7]2=[O:8])[CH2:20][CH2:21][NH:22][CH2:23]1>>[OH:1][CH:2]1[C:3]2([CH2:4][CH2:5][N:6]([c:9]3[cH:10][cH:11][c:12]([O:15][C:16]([F:17])([F:18])[F:19])[cH:13][cH:14]3)[C:7]2=[O:8])[CH2:20][CH2:21][N:22]([S:33]([c:28]2[c:27]([O:26][C:25]([F:24])([F:37])[F:38])[cH:32][cH:31][cH:30][cH:29]2)(=[O:34])=[O:35])[CH2:23]1

Participants

3

Reactant 2

HCID 27772152-(Trifluoromethoxy)benzene-1-sulfonyl chlorideHCID 58056623HCID 58056623, compound

Product 1

HCID 56602662(5RS,6RS)-6-Hydroxy-8-(2-trifluoromethoxy-benzenesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

Sources & evidence

ORD record
ord-80cbbeaa2bf44bc0af300d6cdeae4cbc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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