反应详情

Bromine (9.7 ml) is added to a solution of 2-acetyl-5-methylthiophene (26.6 g) and NaOAc (17.2 g) in water (100 ml) at room temperature. After 12 hours at room temperature the reaction is quenched with a 1M aqueous solution of sodium thiosulfate (100 ml) and extracted three times with ethyl acetate (250 ml). The organic phases are combined, washed with a saturated aqueous solution of NaCl, dried over MgSO4 and concentrated in vacuo to yield 1-(4-bromo-5-methyl-thiophen-2-yl)-ethanone (41.8 g) as a brown oil. The crude product is used without further purification.

1. customAfter 12 hours at room temperature the reaction is quenched with a 1M aqueous solution of sodium thiosulfate (100 ml)
2. extractionextracted three times with ethyl acetate (250 ml)
3. washwashed with a saturated aqueous solution of NaCl
4. dry with materialdried over MgSO4
5. concentrationconcentrated in vacuo