反应详情

t-butyl 2-(2-(3-cyanophenyl)-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)acetate (4) (780 mg; 1.53 mmol) was stirred in a mixture of TFA (15 mL) and DCM (30 mL) for 1 h. After concentration in vacuo, the residue was purified via reversed phase semi-preparative HPLC to yield 303 mg (43.6%) of 2-(2-(3-cyanophenyl)-4-((4-fluoro-N-methylphenylsulfonamido)methyl)phenoxy)acetic acid (Example 5) as a white solid. 1HNMR (CDCl3, 300 MHz): δ 7.84 (m, 3H), 7.75 (m, 1H), 7.61 (m, 1H), 7.50 (t, 1H), 7.24 (m, 3H), 6.85 (d, 1H), 4.69 (s, 2H), 4.13 (s, 2H), 2.63 (s, 3H).

1. concentrationAfter concentration in vacuo
2. customthe residue was purified via reversed phase semi-preparative HPLC