Lithium Hydroxide → HCID 46898402, compound

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To a solution of methyl 2-(2-(3-trifluoromethylphenyl)-4-(1-(4-fluoro-N-methylphenylsulfonamido)ethyl)phenoxy)acetate (19) in MeOH/H2O (4/1) was added lithium hydroxide (2 eq) and the mixture was stirred at room temperature for 2 h. After concentrating in vacuo, the residue was purified via semi-preparative HPLC to give 21.9 mg, (15.2% from Intermediate 18) of 2-(2-(3-trifluoromethylphenyl)-4-(1-(4-fluoro-N-methylphenylsulfonamido)ethyl)phenoxy)acetic acid (Example 22) as white solid. 1HNMR (CDCl3, 400 MHz): δ 7.61 (s, 1H), 7.53 (m, 3H), 7.31 (m, 1H), 7.25 (m, 1H), 7.22 (m, 1H), 7.03 (m, 2H), 6.72 (d, 1H), 5.01 (m, 1H), 4.14 (s, 2H), 2.38 (s, 3H), 1.06 (d, 3H). MS (ES-API): M=323.1 (main fragment). HPLC (Method B) tR=3.43 min.

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