1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carbaldehyde → HCID 67163922, compound

HRID 68632Notes

Reaction equation

HRID 68632 reaction equation
[CH2:1]([N:4]([CH2:10][CH2:11][CH3:12])[CH2:5][CH2:6][CH2:7][CH:8]=O)[CH2:2][CH3:3].C[Si](C)(C)CCOCN1C=CN=C1C=O.[CH3:28][Si:29]([CH3:68])([CH3:67])[CH2:30][CH2:31][O:32][CH2:33][N:34]1[CH:38]=[CH:37][N:36]=[C:35]1[CH2:39][N:40]([CH2:53][C:54]1[N:55]([CH2:59][O:60][CH2:61][CH2:62][Si:63]([CH3:66])([CH3:65])[CH3:64])[CH:56]=[CH:57][N:58]=1)[C:41]([C:43]1[CH:44]=[C:45]2[C:50](=[CH:51][CH:52]=1)[CH2:49][NH:48][CH2:47][CH2:46]2)=[O:42]>>[CH2:1]([N:4]([CH2:10][CH2:11][CH3:12])[CH2:5][CH2:6][CH2:7][CH2:8][N:48]1[CH2:47][CH2:46][C:45]2[C:50](=[CH:51][CH:52]=[C:43]([C:41]([N:40]([CH2:53][C:54]3[N:55]([CH2:59][O:60][CH2:61][CH2:62][Si:63]([CH3:66])([CH3:65])[CH3:64])[CH:56]=[CH:57][N:58]=3)[CH2:39][C:35]3[N:34]([CH2:33][O:32][CH2:31][CH2:30][Si:29]([CH3:67])([CH3:68])[CH3:28])[CH:38]=[CH:37][N:36]=3)=[O:42])[CH:44]=2)[CH2:49]1)[CH2:2][CH3:3]

Participants

4

Reactant 3

HCID 136002351-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carbaldehydeHCID 226111444-(Dipropylamino)butanalHCID 67163688HCID 67163688, compound

Product 1

HCID 67163922HCID 67163922, compound

Procedure

The same procedure as a series of reactions of Example 1 was carried out, except that 4-(dipropylamino)butanal was used in place of 1-({[2-(trimethylsilyl)ethyloxy]methyl}-1H-imidazole-2-carboaldehyde and the compound 13 was used in place of {[4-(methyloxy)phenyl]methyl}amine, to obtain the title compound having the following physical properties.

Sources & evidence

ORD record
ord-1c235ddb74b94f9598dd083cc7e1b950
Source dataset
uspto-grants-2014_09
Patent number
US08822459B2

Reaction notes

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