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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 68637Generated: October 26, 2026

1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carbaldehyde → Methyl 2-[4-(dipropylamino)butyl]-1,2,3,4-tetrahydro-6-isoquinolinecarboxylate

https://huagongshe.com/reaction/68637

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carbaldehydeHCID 13600235—
Reactant4-(Dipropylamino)butanalHCID 22611144—
ReactantMethyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochlorideHCID 42614607—
ProductMethyl 2-[4-(dipropylamino)butyl]-1,2,3,4-tetrahydro-6-isoquinolinecarboxylateHCID 67164447—

Reaction Steps

The same procedure as a series of reactions of Example 1 was carried out, except that 4-(dipropylamino)butanal was used in place of 1-({[2-(trimethylsilyl)ethyloxy]methyl}-1H-imidazole-2-carboaldehyde and methyl 1,2,3,4-tetrahydro-6-isoquinolinecarboxylate hydrochloride was used in place of {[4-(methyloxy)phenyl]methyl}amine, to obtain the title compound having the following physical properties.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08822459B2
Source datasetuspto-grants-2014_09
ORD IDord-f16b09ab72e44430aa31ef3ad1e9af98
Source noteuspto-grants-2014_09