HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carbaldehyde → Methyl 2-[4-(dipropylamino)butyl]-1,2,3,4-tetrahydro-6-isoquinolinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carbaldehyde | HCID 13600235 | — |
| Reactant | 4-(Dipropylamino)butanal | HCID 22611144 | — |
| Reactant | Methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochloride | HCID 42614607 | — |
| Product | Methyl 2-[4-(dipropylamino)butyl]-1,2,3,4-tetrahydro-6-isoquinolinecarboxylate | HCID 67164447 | — |
Reaction Steps
The same procedure as a series of reactions of Example 1 was carried out, except that 4-(dipropylamino)butanal was used in place of 1-({[2-(trimethylsilyl)ethyloxy]methyl}-1H-imidazole-2-carboaldehyde and methyl 1,2,3,4-tetrahydro-6-isoquinolinecarboxylate hydrochloride was used in place of {[4-(methyloxy)phenyl]methyl}amine, to obtain the title compound having the following physical properties.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822459B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-f16b09ab72e44430aa31ef3ad1e9af98 |
| Source note | uspto-grants-2014_09 |