反应详情

In a solution of the compound 29 (2.50 g) in methanol (30 mL), 10% palladium carbon (250 mg) was added under an argon atmosphere. The reaction mixture was stirred under a hydrogen atmosphere at room temperature for 3 hours. The reaction mixture was filtered with Celite (trade name) and the filtrate was concentrated. The residue was purified by silica gel chromatography (n-hexane:ethyl acetate=7:3→3:7) to obtain methyl 4-(6-hydroxyhexyl)benzoate (2.22 g). The same procedure as a series of reactions of Example 25 was carried out, except that methyl 4-(6-hydroxyhexyl)benzoate was used in place of the compound 24, to obtain the title compound having the following physical properties.

1. filtrationThe reaction mixture was filtered with Celite (trade name)
2. concentrationthe filtrate was concentrated
3. customThe residue was purified by silica gel chromatography (n-hexane:ethyl acetate=7:3→3:7)