Methanesulfonyl chloride → N-cyclopropyl-4-fluoro-3-methanesulfonylaminobenzamide

HRID 6868Notes

Reaction equation

HRID 6868 reaction equation
[CH:1]1([NH:4][C:5](=[O:14])[C:6]2[CH:11]=[CH:10][C:9]([F:12])=[C:8]([NH2:13])[CH:7]=2)[CH2:3][CH2:2]1.[CH3:15][S:16](Cl)(=[O:18])=[O:17]>N1C=CC=CC=1>[CH:1]1([NH:4][C:5](=[O:14])[C:6]2[CH:11]=[CH:10][C:9]([F:12])=[C:8]([NH:13][S:16]([CH3:15])(=[O:18])=[O:17])[CH:7]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 219665063-Amino-N-cyclopropyl-4-fluorobenzamide

Product 1

HCID 22019111N-cyclopropyl-4-fluoro-3-methanesulfonylaminobenzamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

N-cyclopropyl-4-fluoro-3-methanesulfonylaminobenzamide was prepared by treatment of N-cyclopropyl-4-fluoro-3-aminobenzamide (prepared by a procedure similar to Example 1) with methanesulfonyl chloride in the presence of pyridine by standard procedure.

Sources & evidence

ORD record
ord-2a2b72a6f89d4c19be519c1cb751c4ae
Source dataset
uspto-grants-2006_08
Patent number
US07084160B2

Reaction notes

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