Methanol → tert-Butyl (3-hydroxycyclobutyl)carbamate

HRID 687124Notes

Reaction equation

HRID 687124 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH:9]1[CH2:10][CH:11]([NH:13][C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[CH2:12]1.[CH3:21][OH:22].[OH-:23].[OH-:25].[Pd+2:24]>>[OH:8][CH:9]1[CH2:10][CH:11]([NH:13][C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[CH2:12]1

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 53415284tert-Butyl [3-(benzyloxy)cyclobutyl]carbamate

Product 1

HCID 22594430tert-Butyl (3-hydroxycyclobutyl)carbamate

Sources & evidence

ORD record
ord-131ede21c8eb4045b854b8b1101b655a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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