3-Fluorophenylboronic acid → 1-(3-Fluoro-phenyl)-3-methylsulfanyl-6-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indazole

HRID 68752Notes

Reaction equation

HRID 68752 reaction equation
C(OC([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[CH:22]=[C:21]3[C:17]([C:18]([S:23][CH3:24])=[N:19][NH:20]3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:25][C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[CH:30][CH:31]=1>>[F:25][C:26]1[CH:31]=[C:30]([N:20]2[C:21]3[C:17](=[CH:16][CH:15]=[C:14]([C:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH:12]=4)[CH:22]=3)[C:18]([S:23][CH3:24])=[N:19]2)[CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 27339863-Fluorophenylboronic acidHCID 674470244-(3-Methylsulfanyl-1H-indazol-6-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Product 1

HCID 566667381-(3-Fluoro-phenyl)-3-methylsulfanyl-6-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indazole

Procedure

The title compound was prepared as a white solid by coupling 4-(3-methylsulfanyl-1H-indazol-6-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester and 3-fluoro-phenyl boronic acid to yield an intermediate, which was de-protected to remove the N-Boc group.

Workup

  1. customto yield an intermediate, which
  2. customto remove the N-Boc group

Sources & evidence

ORD record
ord-80a73feb29934c6eabc18cc191eb27c3
Source dataset
uspto-grants-2014_09
Patent number
US08822447B2

Reaction notes

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