HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonitrile → 1-(3-Isopropyl-1,2,4-oxadiazol-5-YL)piperidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonitrile | HCID 86678210 | — |
| Reactant | HCID 178449908 | HCID 178449908 | — |
| Product | 1-(3-Isopropyl-1,2,4-oxadiazol-5-YL)piperidin-4-one | HCID 66915348 | — |
Reaction Steps
The title compound is prepared from 1,4-dioxa-8-aza-spiro[4.5]decane-8-carbonitrile and N-hydroxy-isobutyramidine following a procedure analogous to that described in Intermediate 5. LC (method 6): tR=1.56 min; Mass spectrum (ESI+): m/z=254 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822471B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-ad2d13b10f764b4ea5437ea707fdebd6 |
| Source note | uspto-grants-2014_09 |