4-(1,3-Oxazol-5-yl)benzoic Acid → HCID 68290188, compound

HRID 68769Notes

Reaction equation

HRID 68769 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][CH:15]2[CH2:17][CH2:16]2)[CH:10]([CH3:18])[CH2:9]1)=O)(C)(C)C.[O:19]1[C:23]([C:24]2[CH:32]=[CH:31][C:27]([C:28](O)=[O:29])=[CH:26][CH:25]=2)=[CH:22][N:21]=[CH:20]1.O1C2(CCN(C#N)CC2)OCC1>>[CH:15]1([N:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH:10]2[CH3:18])[C:28](=[O:29])[C:27]2[CH:26]=[CH:25][C:24]([C:23]3[O:19][CH:20]=[N:21][CH:22]=3)=[CH:32][CH:31]=2)[CH2:16][CH2:17]1

Participants

4

Reactant 3

HCID 27764144-(1,3-Oxazol-5-yl)benzoic AcidHCID 682899444-Cyclopropylamino-3-methyl-piperidine-1-carboxylic acid tert-butyl esterHCID 866782101,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonitrile

Product 1

HCID 68290188HCID 68290188, compound

Procedure

The title compound is prepared from 4-cyclopropylamino-3-methyl-piperidine-1-carboxylic acid tert-butyl ester and 4-oxazol-5-yl-benzoic acid following a procedure analogous to that described in Intermediate 1. LC (method 2): tR=0.84 min; Mass spectrum (ESI+): m/z=326 [M+H]+.

Sources & evidence

ORD record
ord-5c8ef34659c64fc19c88fe13f8c53f40
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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