Cyclopropylamine → N-cyclopropyl-1-(5-methylpyrazin-2-yl)piperidin-4-amine

HRID 68776Notes

Reaction equation

HRID 68776 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[CH:15]1([NH2:18])[CH2:17][CH2:16]1>>[CH:15]1([NH:18][CH:11]2[CH2:12][CH2:13][N:8]([C:5]3[CH:4]=[N:3][C:2]([CH3:1])=[CH:7][N:6]=3)[CH2:9][CH2:10]2)[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 68289948HCID 68289948, compound

Product 1

HCID 68290086N-cyclopropyl-1-(5-methylpyrazin-2-yl)piperidin-4-amine

Procedure

The title compound is prepared from 1-(5-methyl-pyrazin-2-yl)-piperidin-4-one and cyclopropylamine following a procedure analogous to that described in Intermediate 7. LC (method 1): tR=0.68 min; Mass spectrum (ESI+): m/z=233 [M+H]+.

Sources & evidence

ORD record
ord-05a17129f9384f0e8dd288da8eb40b20
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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