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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 68792Generated: October 25, 2026

1,4-Dioxa-8-azaspiro(4.5)decane → 8-(5-Ethylpyrimidin-2-yl)-1,4-dioxa-8-azaspiro[4.5]decane

https://huagongshe.com/reaction/68792

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dioxa-8-azaspiro(4.5)decaneHCID 67435—
Reactant2-Chloro-5-ethylpyrimidineHCID 3572763—
Product8-(5-Ethylpyrimidin-2-yl)-1,4-dioxa-8-azaspiro[4.5]decaneHCID 68290246—

Reaction Steps

The title compound is prepared from 1,4-dioxa-8-azaspiro[4.5]decane and 2-chloro-5-ethyl-pyrimidine following a procedure analogous to that described for Intermediate 61.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08822471B2
Source datasetuspto-grants-2014_09
ORD IDord-145d4d5423a04b1f8263d4e3007f479e
Source noteuspto-grants-2014_09