Cyclopropylamine → N-cyclopropyl-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-amine

HRID 68797Notes

Reaction equation

[CH:1]([C:4]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]2=O)[O:6][N:5]=1)([CH3:3])[CH3:2].[CH:16]1([NH2:19])[CH2:18][CH2:17]1>>[CH:16]1([NH:19][CH:12]2[CH2:13][CH2:14][N:9]([C:7]3[O:6][N:5]=[C:4]([CH:1]([CH3:3])[CH3:2])[N:8]=3)[CH2:10][CH2:11]2)[CH2:18][CH2:17]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 68290265HCID 68290265, compound

Product 1

HCID 68290028N-cyclopropyl-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-amine

Procedure

The title compound is prepared from 1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-2-one and cyclopropylamine following a procedure analogous to that described for Intermediate 66.

Sources & evidence

ORD record: ord-6345da581d924b87852405b01282b915
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08822471B2

Reaction notes

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