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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 68798Generated: October 26, 2026

2-Chloro-5-(trifluoromethyl)pyridine → (3R,4S)-N-Cyclopropyl-3-fluoro-1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-amine

https://huagongshe.com/reaction/68798

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-5-(trifluoromethyl)pyridineHCID 92342—
Reactanttert-butyl N-cyclopropyl-N-[(3R,4S)-3-fluoropiperidin-4-yl]carbamateHCID 68289942—
Product(3R,4S)-N-Cyclopropyl-3-fluoro-1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-amineHCID 68351864—

Reaction Steps

The title compound is prepared from cyclopropyl-[(3R,4S)-3-fluoro-piperidin-4-yl]-carbamic acid tert-butyl ester and 2-chloro-5-trifluoromethyl-pyridine following a procedure analogous to that described for Intermediate 73.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08822471B2
Source datasetuspto-grants-2014_09
ORD IDord-40b3f20939a049d99cf9c3333d5cb29a
Source noteuspto-grants-2014_09