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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 68800Generated: October 25, 2026

2-Chloro-5-ethylpyrimidine → (3R,4S)-Cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-3-fluoro-piperidin-4-yl]-amine

https://huagongshe.com/reaction/68800

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-5-ethylpyrimidineHCID 3572763—
ReactantHCID 68289942HCID 68289942—
Product(3R,4S)-Cyclopropyl-[1-(5-ethyl-pyrimidin-2-yl)-3-fluoro-piperidin-4-yl]-amineHCID 68290756—

Reaction Steps

The title compound is prepared from cyclopropyl-[(3R,4S)-3-fluoro-piperidin-4-yl]-carbamic acid tert-butyl ester and 2-chloro-5-ethyl-pyrimidine following a procedure analogous to that described for Intermediate 73.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08822471B2
Source datasetuspto-grants-2014_09
ORD IDord-4f4240851600414389af3338dc926741
Source noteuspto-grants-2014_09