N-(1-Cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide → N-[1-(3-tert-Butyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide

Participants

Role	Name	HCID	Charge
Reactant	N-(1-Cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide	HCID 86678209	—
Reactant	HCID 178446865	HCID 178446865	—
Product	N-[1-(3-tert-Butyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide	HCID 68351848	—

Reaction Steps

The title compound is prepared from N-(1-cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide and N-hydroxy-2,2-dimethyl-propionamidine following a procedure analogous to that described in Example 1. LC (method 6): tR=1.68 min; Mass spectrum (ESI+): m/z=436 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08822471B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-04627bb7080141bb8a5ebba115e5a252
Source note	uspto-grants-2014_09