N-(1-Cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide → N-Cyclopropyl-N-{1-[3-(4-iodo-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidin-4-yl}-4-oxazol-5-yl-benzamide

HRID 68805Notes

Reaction equation

HRID 68805 reaction equation
[C:1]([N:3]1[CH2:8][CH2:7][CH:6]([N:9]([CH:23]2[CH2:25][CH2:24]2)[C:10](=[O:22])[C:11]2[CH:16]=[CH:15][C:14]([C:17]3[O:21][CH:20]=[N:19][CH:18]=3)=[CH:13][CH:12]=2)[CH2:5][CH2:4]1)#[N:2].[OH:26][NH:27][C:28](=N)[C:29]1[CH:34]=[CH:33][C:32]([I:35])=[CH:31][CH:30]=1>>[CH:23]1([N:9]([CH:6]2[CH2:5][CH2:4][N:3]([C:1]3[O:26][N:27]=[C:28]([C:29]4[CH:34]=[CH:33][C:32]([I:35])=[CH:31][CH:30]=4)[N:2]=3)[CH2:8][CH2:7]2)[C:10](=[O:22])[C:11]2[CH:12]=[CH:13][C:14]([C:17]3[O:21][CH:20]=[N:19][CH:18]=3)=[CH:15][CH:16]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 86678209N-(1-Cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamideHCID 178513329HCID 178513329, compound

Product 1

HCID 68351731N-Cyclopropyl-N-{1-[3-(4-iodo-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidin-4-yl}-4-oxazol-5-yl-benzamide

Procedure

The title compound is prepared from N-(1-cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide and N-hydroxy-4-iodo-benzamidine following a procedure analogous to that described in Example 1. LC (method 6): tR=1.88 min; Mass spectrum (ESI+): m/z=582 [M+H]+.

Sources & evidence

ORD record
ord-41aa5fd54067438e8b5eeb030979da76
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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