2-Chlorobenzoxazole → N-(1-Benzooxazol-2-yl-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide

HRID 68822Notes

Reaction equation

HRID 68822 reaction equation
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:5](=[O:17])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.Cl[C:25]1[O:26][C:27]2[CH:33]=[CH:32][CH:31]=[CH:30][C:28]=2[N:29]=1>>[O:26]1[C:27]2[CH:33]=[CH:32][CH:31]=[CH:30][C:28]=2[N:29]=[C:25]1[N:21]1[CH2:22][CH2:23][CH:18]([N:4]([CH:1]2[CH2:3][CH2:2]2)[C:5](=[O:17])[C:6]2[CH:7]=[CH:8][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[CH:10][CH:11]=2)[CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 119862-ChlorobenzoxazoleHCID 68289931N-Cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide

Product 1

HCID 68290257N-(1-Benzooxazol-2-yl-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide

Procedure

The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide and 2-chloro-benzooxazole following a procedure analogous to that described in Example 19. LC (method 9): tR=1.85 min; Mass spectrum (ESI+): m/z=429 [M+H]+.

Sources & evidence

ORD record
ord-559d177d53f84967bf6bc419db0489a9
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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