5-Bromo-2-fluoropyrimidine → N-[1-(5-Bromo-pyrimidin-2-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide

HRID 68825Notes

Reaction equation

HRID 68825 reaction equation
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:5](=[O:17])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.[Br:24][C:25]1[CH:26]=[N:27][C:28](F)=[N:29][CH:30]=1>>[Br:24][C:25]1[CH:26]=[N:27][C:28]([N:21]2[CH2:22][CH2:23][CH:18]([N:4]([CH:1]3[CH2:3][CH2:2]3)[C:5](=[O:17])[C:6]3[CH:7]=[CH:8][C:9]([C:12]4[O:16][CH:15]=[N:14][CH:13]=4)=[CH:10][CH:11]=3)[CH2:19][CH2:20]2)=[N:29][CH:30]=1

Participants

3

Reactant 2

HCID 6006905-Bromo-2-fluoropyrimidineHCID 68289931N-Cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide

Product 1

HCID 68351944N-[1-(5-Bromo-pyrimidin-2-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide

Procedure

The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide and 5-bromo-2-fluoro-pyrimidine following a procedure analogous to that described in Example 19. LC (method 9): tR=2.32 min; Mass spectrum (ESI+): m/z=468/470 (Br) [M+H]+.

Sources & evidence

ORD record
ord-a71408c9624b46fca458178acc5f1e53
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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