2,5-Dichloropyrimidine → HCID 68290653, compound

HRID 68830Notes

Reaction equation

HRID 68830 reaction equation
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:5](=[O:17])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.Cl[C:25]1[N:30]=[CH:29][C:28]([Cl:31])=[CH:27][N:26]=1>>[Cl:31][C:28]1[CH:27]=[N:26][C:25]([N:21]2[CH2:22][CH2:23][CH:18]([N:4]([CH:1]3[CH2:3][CH2:2]3)[C:5](=[O:17])[C:6]3[CH:7]=[CH:8][C:9]([C:12]4[O:16][CH:15]=[N:14][CH:13]=4)=[CH:10][CH:11]=3)[CH2:19][CH2:20]2)=[N:30][CH:29]=1

Participants

3

Reactant 2

HCID 5906412,5-DichloropyrimidineHCID 68289931N-Cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide

Product 1

HCID 68290653HCID 68290653, compound

Procedure

The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide and 2,5-dichloro-pyrimidine following a procedure analogous to that described in Example 19. LC (method 5): tR=2.27 min; Mass spectrum (ESI+): m/z=424/426 (Cl) [M+H]+.

Sources & evidence

ORD record
ord-b34ed65b6c9c423da4f06064d7b7cab7
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

Loading…