HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 68837Generated: October 29, 2026
Isopropanol → N-Cyclopropyl-N-[1-(3-isopropoxy-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide
https://huagongshe.com/reaction/68837
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | N-[1-(3-Chloro-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide | HCID 68290214 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N-Cyclopropyl-N-[1-(3-isopropoxy-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide | HCID 68351852 | — |
Reaction Steps
A mixture of N-[1-(3-chloro-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide (43 mg), isopropanol (2.0 mL), and cesium carbonate (98 mg) in N-methyl-2-pyrrolidinon (2.0 mL) is stirred at 125° C. for three days. The mixture is separated by HPLC (MeOH/H2O/TFA) to give the title compound. LC (method 5): tR=2.14 min; Mass spectrum (ESI+): m/z=454 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08822471B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-c7cc8e98d6e94c7e9747bf249fa2d017 |
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| Source note | uspto-grants-2014_09 |
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