N-(1-Cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide → N-{1-[3-(4-Bromo-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidin-4-yl}-N-cyclopropyl-4-oxazol-5-yl-benzamide

HRID 68838Notes

Reaction equation

HRID 68838 reaction equation
[C:1]([N:3]1[CH2:8][CH2:7][CH:6]([N:9]([CH:23]2[CH2:25][CH2:24]2)[C:10](=[O:22])[C:11]2[CH:16]=[CH:15][C:14]([C:17]3[O:21][CH:20]=[N:19][CH:18]=3)=[CH:13][CH:12]=2)[CH2:5][CH2:4]1)#[N:2].[Br:26][C:27]1[CH:36]=[CH:35][C:30]([C:31]([NH:33][OH:34])=N)=[CH:29][CH:28]=1>>[Br:26][C:27]1[CH:36]=[CH:35][C:30]([C:31]2[N:2]=[C:1]([N:3]3[CH2:4][CH2:5][CH:6]([N:9]([CH:23]4[CH2:25][CH2:24]4)[C:10](=[O:22])[C:11]4[CH:12]=[CH:13][C:14]([C:17]5[O:21][CH:20]=[N:19][CH:18]=5)=[CH:15][CH:16]=4)[CH2:7][CH2:8]3)[O:34][N:33]=2)=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 86678209N-(1-Cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamideHCID 178513245HCID 178513245, compound

Product 1

HCID 60194755N-{1-[3-(4-Bromo-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidin-4-yl}-N-cyclopropyl-4-oxazol-5-yl-benzamide

Procedure

The title compound is prepared from N-(1-cyano-piperidin-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide and 4-bromo-N-hydroxy-benzamidine following a procedure analogous to that described in Example 1. LC (method 6): tR=2.08 min; Mass spectrum (ESI+): m/z=534/536 (Br) [M+H]+.

Sources & evidence

ORD record
ord-5445f4bb82114bd2ad450dccf45b281e
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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