HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-3-phenyl-1,2,4-oxadiazole → N-Cyclopropyl-N-[3-methyl-1-(3-phenyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-3-phenyl-1,2,4-oxadiazole | HCID 12728443 | — |
| Reactant | N-cyclopropyl N-(3-methylpiperidin-4-yl)-4-oxazol-5-ylbenzamide | HCID 68290188 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N-Cyclopropyl-N-[3-methyl-1-(3-phenyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-4-oxazol-5-yl-benzamide | HCID 68351880 | — |
Reaction Steps
The title compound is prepared from N-cyclopropyl-N-(3-methyl-piperidin-4-yl)-4-oxazol-5-yl-benzamide and 5-chloro-3-phenyl-[1,2,4]oxadiazole following a procedure analogous to that described in Example 19 using N-methylpyrrolidinone as solvent. LC (method 3): tR=2.01 min; Mass spectrum (ESI+): m/z=470 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822471B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-4e63bb6669e042a7a0fc0e1a0bb49754 |
| Source note | uspto-grants-2014_09 |