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Potassium Carbonate → N-(5'-Bromo-3'-fluoro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5-Bromo-2,3-difluoropyridine | HCID 14549654 | — |
| 反応物 | N-Cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide | HCID 68289931 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | N-(5'-Bromo-3'-fluoro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide | HCID 68289592 | — |
反応手順
The title compound is prepared from N-Cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide and 5-bromo-2,3-difluoro-pyridine following a procedure analogous to that described in Example 61 using K2CO3 as base and N-methylpyrrolidinone as solvent. LC (method 1): tR=1.35 min; Mass spectrum (ESI+): m/z=507 [M+Na]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822471B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-8c16364015134bdeb4777619505b92c1 |
| 出典メモ | uspto-grants-2014_09 |