Ethanol → 5-[4-(1-Hydroxy-1-methylethyl)phenyl]-2-({6-[(2-hydroxy-2-methylpropoxy)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide
Reaction equation
[Br:20][c:21]1[cH:22][cH:23][cH:24][c:25]([CH2:27][O:28][CH2:29][C:30]([CH3:31])([OH:32])[CH3:33])[n:26]1.[CH3:96][CH2:97][OH:98].[K+:34].[K+:35].[NH2:1][c:2]1[s:3][c:4](-[c:10]2[cH:11][cH:12][c:13]([C:16]([CH3:17])([CH3:18])[OH:19])[cH:14][cH:15]2)[cH:5][c:6]1[C:7](=[O:8])[NH2:9].[O-:36][C:37]([O-:38])=[O:39].[O:42]=[C:43]([CH:44]=[CH:45][c:46]1[cH:47][cH:48][cH:49][cH:50][cH:51]1)[CH:52]=[CH:53][c:54]1[cH:55][cH:56][cH:57][cH:58][cH:59]1.[O:60]=[C:61]([CH:62]=[CH:63][c:64]1[cH:65][cH:66][cH:67][cH:68][cH:69]1)[CH:70]=[CH:71][c:72]1[cH:73][cH:74][cH:75][cH:76][cH:77]1.[O:78]=[C:79]([CH:80]=[CH:81][c:82]1[cH:83][cH:84][cH:85][cH:86][cH:87]1)[CH:88]=[CH:89][c:90]1[cH:91][cH:92][cH:93][cH:94][cH:95]1.[Pd:40].[Pd:41]>>[NH:1]([c:2]1[s:3][c:4](-[c:10]2[cH:11][cH:12][c:13]([C:16]([CH3:17])([CH3:18])[OH:19])[cH:14][cH:15]2)[cH:5][c:6]1[C:7](=[O:8])[NH2:9])[c:21]1[cH:22][cH:23][cH:24][c:25]([CH2:27][O:28][CH2:29][C:30]([CH3:31])([OH:32])[CH3:33])[n:26]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-af88a1e00ff34c4e80320e8f92ff9a76
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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