HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-5-phenyl-1,3,4-thiadiazole → N-Cyclopropyl-4-oxazol-5-yl-N-[1-(5-phenyl-[1,3,4]thiadiazol-2-yl)-piperidin-4-yl]-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-5-phenyl-1,3,4-thiadiazole | HCID 253145 | — |
| Reactant | N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride | HCID 68289930 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | N-Cyclopropyl-4-oxazol-5-yl-N-[1-(5-phenyl-[1,3,4]thiadiazol-2-yl)-piperidin-4-yl]-benzamide | HCID 68351881 | — |
Reaction Steps
The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride and 2-chloro-5-phenyl-[1,3,4]thiadiazole following a procedure analogous to that described in Example 19 using N-methylpyrrolidinone as solvent. LC (method 16): tR=0.49 min; Mass spectrum (ESI+): m/z=472 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822471B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-bf791a31b582406f90dd315701f45076 |
| Source note | uspto-grants-2014_09 |